Research Article | Volume : 2 Issue : 1, January 2012

Quantitative determination of Cimetidine in both bulk and formulations using neutralization titrations

Manish Kumar Thimmaraju Khaggeswar Bheemanapally J. Venkateshwar Rao KRS. Sambasiva Rao Raghunandan Nerella   

Open Access   


Cimetidine is the selective H2 receptor antagonist and inhibits the secretion of hydrochloric acid in the stomach. In the present study, simple titrimetric method was developed. Respective quantities of Cimetidine were taken in aqueous methanol and acetic acid titrated against 0.1N hydrochloric acid and 0.1N perchloric acid using methyl orange and crystal violet as indicators for neutralization and non-aqueous titrations. All the titrations are carried out by running simultaneous blank determinations. The final titer values are subtracted from blank to get actual amount of acid consumed was determined. These methods were found to be sensitive and inexpensive, do not require any sample processing steps and can be utilized for estimation of cimetidine in bulk and formulations.

Keyword:     Cimetidine titrimetric analysis neutralization non-aqueous titration H2 receptor antagonist assay of cimetidine.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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