Review Article | Volume: 11, Supplement 1, March, 2021

Chalcones: A review on synthesis and pharmacological activities

Kamya Goyal Rajwinder Kaur Anju Goyal Rajendra Awasthi   

Open Access   

Published:  Feb 11, 2021

DOI: 10.7324/JAPS.2021.11s101
Abstract

Chalcone is a privileged species with medicinal significance as it consists of reactive ketoethylenic moiety –CO– CH=CH– belonging to flavonoids. The presence of a reactive α, β-unsaturated carbonyl function in chalcone and its derivatives is the reason for its pharmacological activities. Chalcones exhibit a wide spectrum of pharmacological effects such as antioxidant, antibacterial, anthelmintic, antiulcer, antiviral, insecticidal, antiprotozoal, anticancer, antiinflammatory, antidiabetic, etc. Chalcones can be synthesized by Claisen–Schmidt’s condensation, Heck’s reaction, Suzuki’s reaction, etc. The purpose of this review is to focus on the methods of synthesis of chalcones and their versatile pharmacological activities.


Keyword:     Chalcone Claisen–Schmidt condensation anticancer antimicrobial antidiabetic.


Citation:

Goyal K, Kaur R, Goyal A, Awasthi R. Chalcones: A review on synthesis and pharmacological activities. J Appl Pharm Sci, 2021; 11 (Supp 1):001–014.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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