Review Article | Volume : 1 Issue : 10, December 2011

Prion diseases: A challenge to animal health

Dudhatra G.B. Mody S.K. Patel H.B. Modi C.M. Avinash Kumar Awale M.M.   

Open Access   


Prion diseases are known as transmissible spongiform encephalopathies (TSE), a group of rare, rapidly progressive, and fatal neurologic diseases. The agents responsible for human and animal prion diseases are abnormal proteins (prion or proteinaceous infectious particle) that can trigger chain reactions causing normal proteins in the brain to change to the abnormal protein. These abnormal proteins are resistant to enzymatic breakdown, and they accumulate in the brain, leading to damage. All have long incubation periods followed by chronic neurological disease and fatal outcomes, have similar pathology limited to the CNS include convulsions, dementia, ataxia (balance and coordination dysfunction), and behavioral changes, and are experimentally transmissible to some other species.

Keyword:     Bovine spongiform encephalopathy Chronic wasting disease Exotic ungulate encephalopathy Feline spongiform encephalopathy Mad cow disease Prion Scrapie and Transmissible mink encephalopathy.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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