Research Article | Volume : 1 Issue : 10, December 2011

Development of validated liquid chromatographic method for estimation of levocetirizine from pharmaceutical dosage forms

Chaitanya Prasad MK Vidyasagar G Sambasiva Rao KRS Madhusudhanareddy Induri Ramanjeneyulu S   

Open Access   


A simple and rapid high-performance liquid chromatographic (HPLC) method for the determination levocetirizine has been developed. The chromatographic system consisted of a Water 2695 binary gradient pump, Water 2487 dual wavelength absorbance detector, and Empower 2 software. Separation was achieved on the XTerra symmetry C18 column at room temperature. The sample was introduced through an injector valve with a 20 μL sample loop. The results obtained showed a good agreement with the declared content. Recovery values of levocetirizine in tablets were from 99.57-100.48 %. The proposed method is rapid, accurate and selective; it may be usedfor the quantitative analysis of levocetirizine from raw materials, in bulk drugs and other dosage formulations.

Keyword:     Levocetirizine Tablets Reverse phase HPLC and Quality control.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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