Published:  Nov 30, 2018DOI: 10.7324/JAPS.2018.81101
A series of 2-(4-(methylsulfonyl)phenyl)-1-substituted-indole derivatives 4a–f was designed and synthesized as indomethacin analogs; All synthesized compounds were assessed for their in vitro COX-2 inhibition effect as well as in vivo anti-inflammatory activity using indomethacin as a reference drug. All synthesized compounds showed good anti-inflammatory activity and more selectivity for COX-2 inhibition. A molecular modeling study was carried out and the results were compatible with that derived from in vitro COX-2 inhibition assays.
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