Mini Review | Volume: 8, Issue: 10, October, 2018

Synovium Targeting Delivery of TNFα Blocker for Rheumatoid Arthritis Therapy - A Mini Review

Riyona Desvy Pratiwi Muhammad Novrizal Abdi Sahid   

Open Access   

Published:  Oct 31, 2018

DOI: 10.7324/JAPS.2018.81021

Tumor necrosis factor α (TNFα) blockers are proven to be potential suppressing agents for rheumatoid arthritis. Aside from showing significant effects in clinical treatment, they are also known as the top-selling biological agents. However, several systemic side effects related to infection and cancer are shown after treatments with systemic TNFα blockers. In order to reduce and overcome the side effects, a targeted delivery is then requested. Synovium or synovial membrane is considered as a promising delivery target because TNFα is highly accumulated within it. The current article reviews a number of strategies that might be applied in the synovium targeting delivery of TNFα blockers.

Keyword:     Rheumatoid arthritis tumor necrosis factor α blockers synovium targeted delivery.


Pratiwi RD, Sahid MNA. Synovium Targeting Delivery of TNFα Blocker for Rheumatoid Arthritis Therapy – A Mini Review. J App Pharm Sci, 2018; 8(10): 165-171.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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