Research Article | Volume: 8, Issue: 8, August, 2018

Novel synthetic analogues of Fluoxetine as potent and selective anti-TB agents

M. Murali Krishna Kumar K. Madhavi T. Mohan K. Purna Nagasree G. P. V. Sangeeta   

Open Access   

Published:  Aug 31, 2018

DOI: 10.7324/JAPS.2018.8815
Abstract

We have recently identified potent anti-TB activity in several CNS drugs. Most prominently, the phenothiazine antipsychotics (Thioridazine-MIC 3.125 μg/mL) and anti-depressant drugs (sertraline-MIC 1.6 μg/mL) have shown anti-TB activity against Mycobacterium tuberculosis H37Rv. In continuation, we have synthesized a series of 1-(3-aryloxy-3-phenylpropyl) amine analogues of fluoxetine to optimize its anti-TB activity. Identities of the synthesized compounds were confirmed by FTIR, 1H NMR and mass spectral analysis. They were tested for in vitro antitubercular activity by MABA Assay. To determine selective TB activity, they were also tested for antimicrobial activity. Among the synthesized compounds, 1-(3-(4-fluorophenoxy)-3-phenylpropyl) piperidine (AM3e) has shown highest anti-TB activity (MIC 1.6 μg/mL) against MtbH37Rv and is free from antibacterial/antifungal activity (MIC >100 μg/mL).


Keyword:     Acetophenone mannichbases fluoxetineantitubercular activity drugrepurposing.


Citation:

Kumar MMK, Madhavi K, Mohan T, Nagasree KP, Sangeeta GPV. Novel synthetic analogues of Fluoxetine as potent and selective anti-TB agents . J App Pharm Sci, 2018; 8(08): 107-115.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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