Research Article | Volume: 8, Issue: 8, August, 2018

HPMC K15M and Carbopol 940 mediated fabrication of ondansetron hydrochloride intranasal mucoadhesive microspheres

Poonam Dhawale Nilesh M. Mahajan Debarshi Kar Mahapatra Ujwala N. Mahajan Purushottam S. Gangane   

Open Access   

Published:  Aug 31, 2018

DOI: 10.7324/JAPS.2018.8812

The purpose of the present research was the design, development, and evaluation of ondansetron hydrochloride loaded polymeric mucoadhesive microspheres for intranasal delivery to avoid first-pass metabolism phenomenon in the liver and to improve its residence time. The microspheres were fabricated by a solvent evaporation method using carbopol 940 and HPMC K15M as a mucoadhesive polymer along with ethyl cellulose as a film-forming polymer. The intention of the current study was to comprehensively examine the influence of formulation components and the probable process variables such as a polymer to polymer ratio and stirring rate on the characteristics of the microspheres prepared. The microspheres were characterized for drug-polymer interactions, entrapment efficiency, drug loading, swelling property, particle size analysis, thermal behavior, morphological, in-vitro mucoadhesion, ex-vivo drug permeation, in-vitro drug release, histopathology, and release kinetic studies. The research will open new avenues for increasing the bioavailability of ondansetron hydrochloride in the future.

Keyword:     Nasal drug deliveryMucoadhesiveMicrosphere Solventevaporation techniqueOndansetron hydrochlorideBioavailability.


Dhawale P, Mahajan NM, Mahapatra DK, Mahajan UN, Gangane PS. HPMC K15M and Carbopol 940 mediated fabrication of ondansetron hydrochloride intranasal mucoadhesive microspheres. J App Pharm Sci, 2018; 8(08): 075-083.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

HTML Full Text


Abbas Z, Marihal S, Akifuddin SK. Almotriptan loaded sodium alginate microspheres for nasal delivery: formulation optimization using factorial design, characterization and in-vitro evaluation. Ind J Novel Drug Deliv, 2014; 6(1):10-24.

Abbas Z, Marihal S. Gellan gum based mucoadhesive microspheres of almotriptan for nasal administration: Formulation optimization using factorial design, characterization, and in vitro evaluation. J Pharm Bioall Sci, 2014a; 6(4):267-77.

Behl CR, Pimplaskar HK, Sileno AP, deMeireles J, Romeo VD. Effects of physicochemical properties and other factors on systemic nasal drug delivery. Adv Drug Deliv Rev, 1998; 29:89-116.

Dandge BH, Dehghan MH. Formulation and evaluation of nasal mucoadhesive microparticles of diltiazem hydrochloride. Int J ChemTech Res, 2009; 1(4):1036-1042.

Dangre PV, Godbole MD, Ingle PV, Mahapatra DK. Improved Dissolution and Bioavailability of Eprosartan Mesylate Formulated as Solid Dispersions using Conventional Methods. Indian J Pharm Edu Res, 2016; 50(3):S209-S217.

Desai S, Vidyasagar G, Shah V, Desai D. Preparation and in vitro characterisation of mucoadhesive microspheres of midazolam: nose to brain administration. Asian J Pharm Clin Res, 2011; 4(1):100-102.

Godbole MD, Mahapatra DK, Khode PD. Fabrication and Characterization of Edible Jelly Formulation of Stevioside: A Nutraceutical or OTC Aid for the Diabetic Patients. Inventi Rapid: Nutraceuticals, 2017; 2017(2):1-9.

Jain BK. Preparation and in vitro characterization of mucoadhesive Norethisterone-egg albumin microspheres for nasal administration. Asian J Biomed Pharm Sci, 2012; 2(15):49-57.

Jain SA, Chauk DS, Mahajan HS, Tekade AR, Gattani SS. Formulation and evaluation of nasal mucoadhesive microspheres of Sumatriptan succinate. J Microencapsul, 2009; 26(8):711-721.

Kashikar V, Dhole S, Kandekar U, Khose P. Study of mucoadhesive microsphere of pirfenidone for nasal drug delivery. Asian J Pharm, 2014; 8(1):46-53.

Kulkarni AD, Bari DB, Surana SJ, Pardeshi CV. In vitro, ex vivo and in vivo performance of chitosan-based spray-dried nasal mucoadhesive microspheres of diltiazem hydrochloride. J Drug Deliv Sci Tech, 2016; 31:108-117.

Mahajan HS, Tatiya BV, Nerkar PP. Ondansetron loaded pectin based microspheres for nasal administration: In vitro and in vivo studies. Powder Tech, 2012; 221:168-176.

Mahajan NM, Pardeshi A, Mahapatra DK, Darode A, Dumore NG. Hypromellose and Carbomer induce bioadhesion of Acyclovir tablet to vaginal mucosa. Indo Am J Pharm Res, 2017; 7(12):1108-1118.

Mahajan NM, Wadhwane P, Mahapatra DK. Rational designing of sustained release matrix formulation of Etodolac employing Hypromellose, Carbomer, Eudragit and Povidone. Int J Pharm Pharm Sci, 2017; 9(12):92-97.

Mahajan H, Gattani S, Surana S. Spray dried mucoadhesive microspheres of ondansetron for nasal administration. Int J Pharm Sci Nanotechnol, 2008; 1(3):267-274.

Mahapatra DK, Bharti SK. Handbook of Research in Medicinal Chemistry. Ontario, India: Apple Academic Press. 2017.

Mahapatra DK, Bharti SK. Medicinal Chemistry with Pharmaceutical Product Development. Ontario, India: Apple Academic Press. 2018.

Mahapatra DK, Bharti SK. Drug Design. New Delhi, India: Tara Publications Private Limited. 2016.

Nanjwade BK, Parikh KA, Deshmukh RV, Najwade VK, Gaikwad KR, Thakare SA, Manvi FV. Development and evaluation of intranasal mucoadhesive microspheres of neostigmine bromide. Pharm Anal Acta, 2011; 2(2):1-6.

Pagar SA, Shinkar DM, Saudagar RB. A review on intranasal drug delivery system. J Adv Pharm Edu Res, 2013; 3(4):333-346.

Pardeshi CV, Rajput PV, Belgamwar VS, Tekade AR. Formulation, optimization and evaluation of spray dried mucoadhesive microspheres as intranasal carriers for Valsartan. J Microencapsul, 2012; 29(2):103-114.

Patil MD, Mahapatra DK, Dangre PV. Formulation and in-vitro evaluation of once-daily sustained release matrix tablet of nifedipine using rate retardant polymers. Inventi Rapid: Pharm Tech, 2016; 2016(4):1-7.

Pilicheva B, Zagorchev P, Uzunova Y, Kassarova M. Development and in vitro evaluation of mucoadhesive microsphere carriers for intranasal delivery of betahistine dihydrochloride. Int J Drug Dermatol, 2013; 5(3):389-401.

Prasanth VV, Chakraborty A, Mathew ST, Mathappan R, Kamalakkannan V. Formulation and evaluation of salbutamol sulphate microspheres by solvent evaporation method. J Appl Pharm Sci, 2011; 1(5):133-137.

Shahi SR, Tribhuwan SD, Tadwee IK, Gupta SK, Zadbuke NS, Shivanikar SS. Formulation of atenolol mucoadhesive microspheres for nasal delivery by spray drying technique: in vitro/ex vivo evaluation. Der Pharm Sinica, 2011; 2(5):54-63.

Sonkusre N, Dhabarde DM, Mahapatra DK. Formulation and development of mirtazapine self emulsifying drug delivery system (SEDDS) for enhancement of dissolution profile. Inventi NDDS, 2016(3):1-9.

Swamy NG, Abbas Z. Preparation and in vitro characterization of mucoadhesive hydroxypropyl guar microspheres containing amlodipine besylate for nasal administration. Indian J Pharm Sci, 2011; 73(6):608-614.

Taksande JB, Umekar MJ. Preparation of intranasal pregabalin microspheres: In vitro, ex vivo and in vivo pharmacodynamic evaluation. J Pharm Res, 2018; 12(1):112-121.

Umaredkar AA, Dangre PV, Mahapatra DK, Dhabarde DM. Fabrication of chitosan-alginate polyelectrolyte complexed hydrogel for controlled release of cilnidipine: a statistical design approach. Mater Technol, 2018; 1:1-11.

Article Metrics
625 Views 75 Downloads 700 Total



Related Search

By author names