Research Article | Volume: 8, Issue: 7, July, 2018

Mild Permanent Chronic Thyroid Hormones Insufficiency Induces Cognitive Dysfunction in the Adult Male and Female Rats

Mahdieh Taheri,  Tahereh Haghpanah,  Gholam Hossein Meftahi,  Mohsen Abedini Esfahlani,  Fatemeh Gloshan,  Khadijeh Esmailpour,  Iman Znangiabadi,  Yaser Masoumi-Ardakani,  Fatemeh Nouri,  Vahid Sheibani,  Mohammad Reza Afarinesh   
Mahdieh Taheri1, Tahereh Haghpanah2, Gholam Hossein Meftahi3, Mohsen Abedini Esfahlani2, Fatemeh Gloshan1, Khadijeh Esmailpour1, Iman Znangiabadi2, Yaser Masoumi-Ardakani4, Fatemeh Nouri1, Vahid Sheibani1, Mohammad Reza Afarinesh1

1Kerman Cognitive Research Center and Kerman Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.

2Department of anatomy, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

3Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.

4Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.

Open Access   

Published:  Jul 30, 2018

DOI: 10.7324/JAPS.2018.8716
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Abstract

Objectives: Hypothyroidism is believed to result in irreversible neurological and cognitive impairments. The aim of this study was to examine cognitive functions of male and female rat offspring exposed to 6-propyl-2-thiouracil (PTU) following levothyroxine-therapy. Materials and Methods: Wistar rats were used for the experiment. To induce chronic mild neonatal hypothyroidism in rat offspring, PTU (1.5, 3, and 6 ppm) was added to drinking water of the rat offspring from postnatal day 1 to week 12. In the separated group, levothyroxine (50 mg/kg. SC) was injected in the Hypo 6 ppm. Morris water maze (MWM) and novel object recognition (NOR) tests were performed at weeks 10 and 12 respectively. Results: In both male and female rats, there was an increase (P < 0.05) in neonatal hypothyroid rats’ escape latency and traveled distance to find the hidden platform in MWM compared to those of control. Retrieval memory was impaired in the MWM and the NOR tests. Levothyroxine-therapy resulted in a non-significant difference in the traveled distance and latency delay and retrieval memory of the hypo 6 ppm group compared to controls (P > 0.05). Conclusions: Cognitive impairments following neonatal mild hypothyroidism can disturb hippocampus-dependent learning and memory in both male and female rats. Treatment with levothyroxine induces an improvement in disorders of both male and female genders.


Keyword:     Neonatal hypothyroidism Spatial learning Morris Water Maze Novel object recognition Rats.

Citation:

Taheri M, Haghpanah T, Meftahi GH, Abedini-Esfahlani M, Gloshan F, Esmailpour K, Znangiabadi I, Masoumi-Ardakani Y, Nouri F, Sheibani V, Afarinesh M. Mild Permanent Chronic Thyroid Hormone Insufficiency Induces Cognitive Dysfunction in the Adult Male and Female Rats. J App Pharm Sci, 2018; 8(07): 100-106.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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