Research Article | Volume: 8, Issue: 7, July, 2018

Mild Permanent Chronic Thyroid Hormones Insufficiency Induces Cognitive Dysfunction in the Adult Male and Female Rats

Mahdieh Taheri Tahereh Haghpanah Gholam Hossein Meftahi Mohsen Abedini Esfahlani Fatemeh Gloshan Khadijeh Esmailpour Iman Znangiabadi Yaser Masoumi-Ardakani Fatemeh Nouri Vahid Sheibani Mohammad Reza Afarinesh   

Open Access   

Published:  Jul 30, 2018

DOI: 10.7324/JAPS.2018.8716

Objectives: Hypothyroidism is believed to result in irreversible neurological and cognitive impairments. The aim of this study was to examine cognitive functions of male and female rat offspring exposed to 6-propyl-2-thiouracil (PTU) following levothyroxine-therapy. Materials and Methods: Wistar rats were used for the experiment. To induce chronic mild neonatal hypothyroidism in rat offspring, PTU (1.5, 3, and 6 ppm) was added to drinking water of the rat offspring from postnatal day 1 to week 12. In the separated group, levothyroxine (50 mg/kg. SC) was injected in the Hypo 6 ppm. Morris water maze (MWM) and novel object recognition (NOR) tests were performed at weeks 10 and 12 respectively. Results: In both male and female rats, there was an increase (P < 0.05) in neonatal hypothyroid rats’ escape latency and traveled distance to find the hidden platform in MWM compared to those of control. Retrieval memory was impaired in the MWM and the NOR tests. Levothyroxine-therapy resulted in a non-significant difference in the traveled distance and latency delay and retrieval memory of the hypo 6 ppm group compared to controls (P > 0.05). Conclusions: Cognitive impairments following neonatal mild hypothyroidism can disturb hippocampus-dependent learning and memory in both male and female rats. Treatment with levothyroxine induces an improvement in disorders of both male and female genders.

Keyword:     Neonatal hypothyroidism Spatial learning Morris Water Maze Novel object recognition Rats.


Taheri M, Haghpanah T, Meftahi GH, Abedini-Esfahlani M, Gloshan F, Esmailpour K, Znangiabadi I, Masoumi-Ardakani Y, Nouri F, Sheibani V, Afarinesh M. Mild Permanent Chronic Thyroid Hormone Insufficiency Induces Cognitive Dysfunction in the Adult Male and Female Rats. J App Pharm Sci, 2018; 8(07): 100-106.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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