Three simple and sensitive methods were developed for the determination of a mixture of Rabeprazole sodium RB and Domperidone DP without prior separation. The first method A, isoabsorptive point comprised of measurement the total content of the mixture at their isoabsorptive point, while the content of RB was determined by measuring the first order derivative of its spectra at 231 nm, and the content of DP could be calculated by subtraction. The second method, B was based on the mean centering of ratio spectra, the concentration of RB was determined by measuring the amplitude at 256.4 nm and the concentration of DP was determined by measuring the amplitude at 311.8 nm. The third method C, dual wavelength method, the wavelengths selected for determination of Rabeprazole were 270 nm & 301 nm, whereas, the wavelengths selected for determination of Domperidone were 260 and 297.2 nm. The percentages mean accuracy for RB were 99.74 ± 0.498 % for method (A), 100.52 ± 0.478 % for (B) and 100.43 ± 0.502 % for (C) respectively. And that of DP were 100.28 ± 0.488 % for method (A), 99.24 ± 0.551 % for (B) and 99.95 ± 0.516 % for (C) respectively. The obtained results were statistically compared with those obtained by the official methods, showing no significant difference with respect to accuracy and precision.
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