Research Article | Volume: 8, Issue: 6, June, 2018

Identification of the Phytochemical Compounds and Their Type I Procollagen Induction in Astragalus membranaceus Sprouts Grown under Different Light Conditions

Seon Young Jeong Mi Yeon Moon Eun Kyung Ryu Je Sung Lee Joonseok Cha   

Open Access   

Published:  Jun 29, 2018

DOI: 10.7324/JAPS.2018.8601
Abstract

Astragalus membranaceus, a medicinal herb, has been used for diuretic, tonic, anti-viral and antioxidant effects. Its root is widely used in Chinese and Korean traditional medicines, but in this study, the sprout grown optimally in our indoor system was evaluated for cosmetic efficacies. Interestingly, A. membranaceus sprout extract activated the production of type I procollagen by human dermal fibroblast cells in a dose-dependent manner, without showing cell toxicity. A phytochemical study was conducted to identify the active constituents in the extract by solvent fractionation and column purifications. As a result, three compounds: tryptophan (1), linoleic acid (2) and adenine (3) were identified by NMR spectroscopy. Isolated tryptophan was verified to induce the synthesis of the type I procollagen in a dose-dependent manner. These results demonstrate that A. membranaceus sprouts containing tryptophan can be developed as skin care ingredient with the optimization of indoor cultivation system.


Keyword:     A. membranaceus sprout hwanggi tryptophan type 1 procollagen.


Citation:

Jeong SY, Moon MY, Ryu EK, Lee JS, Cha J. Identification of the Phytochemical Compounds and Their Type I Procollagen Induction in Astragalus membranaceus Sprouts Grown under Different Light Conditions. J App Pharm Sci, 2018; 8(06): 001- 007.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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