Research Article | Volume: 8, Issue: 5, May, 2018

Entada rheedii seeds thioamides, phenolics, and saponins and its antiulcerogenic and antimicrobial activities

Mona M. Okba,  Sally A.W. El Awdan,  Miriam F. Yousif ,  Kadriya S. El Deeb,  Fathy M. Soliman   
Mona M. Okba1, Sally A.W. El Awdan2, Miriam F. Yousif1 & 3, Kadriya S. El Deeb1, Fathy M. Soliman1

1Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr-El-Ainy St., Cairo 11562, Egypt.

2Pharmacology Department, National Research Center, El-Tahrir St., Dokki, Cairo 12622, Egypt.

3Department of Pharmacognosy and Medicinal Plants, Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Future University, Al Tagamoa Al Khames, 11528, New Cairo, Egypt.

Open Access   

Published:  May 30, 2018

DOI: 10.7324/JAPS.2018.8513
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Abstract

Entada rheedii (Fabaceae) seeds are used against diarrhea and stomach aches. This study aims at scientifically validate its ethnomedicinal uses. Seeds ethanol (70%) extract (EE) was prepared by percolation. Antibacterial and antiviral activities of EE and isolated compounds were determined using agar well diffusion and MTT assays, respectively. Anti-ulcerogenic activity was evaluated using ethanol-induced ulcer model. Four phenolics: protocatechuic acid C1, protocatechuic acid methyl ester C2, 1,3,4-trihydroxybenzene glucoside C3, phaseoloidin C4, three thioamides: entadamide A C5, entadamide A-β-d-glucopyranoside C6, entadamide C C7, and two saponins: rheedeioside A C8 and rheedeioside B C9 were isolated from EE. EE, C4, C5, and C8 evidenced significant (p Ë‚ 0.05) antiulcerogenic activity. Strong antibacterial activity was reported for EE, C1, and C7. C4 exhibited moderate (35% inhibition) antiviral activity. This study provides scientific validation of the seed ethnomedicinal use in treating gastric ailments and as antimicrobial.


Keyword:     Entada rheedii rheedeioside A entadamide A phaseoloidin gastric ulcer antibacterial.

Citation:

Okba MM, El Awdan SAW, Yousif MF, El Deeb KS, Soliman FM. Entada rheedii seeds thioamides, phenolics, and saponins and its antiulcerogenic and antimicrobial activities. J App Pharm Sci, 2018; 8(05): 101-108.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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