Research Article | Volume: 8, Issue: 5, May, 2018

Development and optimization of microparticles containing a hypoglycemic fraction of calyces from Physalis peruviana

Sandra Milena Echeverry Ivonne Helena Valderrama Geison M. Costa Luis Fernando Ospina-Giraldo Diana Marcela Aragón   

Open Access   

Published:  May 30, 2018

DOI: 10.7324/JAPS.2018.8502

Physalis peruviana L. (Cape gooseberry) is a plant widely cultivated in the Andean mountain in South America and its calyces are the main by-product of the harvest and commercialization of the fruits. Hypoglycemic activity was evaluated to the hydroethanolic extract and its fractions by glucose tolerance test. Since butanolic fraction exhibited hypoglycemic activity as well as the hydroethanolic extract, this fraction was microencapsulated in hypromellose phthalate (HPMCP) by the emulsification-evaporation method. Rutin was the major flavonoid in the whole extract and butanolic fraction. By using Plackett-Burman and Box-Behnken statistical experimental designs, were developed and optimized HPMCP-microparticles loaded with butanolic fraction. Optimized microparticles have an entrapment efficiency of 71% and yield of 64%, only 8% of release at acidic pH and significant hypoglycemic activity. Development and optimization of microencapsulated butanolic fraction of calyces from P. peruviana is an important contribution to improve its hypoglycemic activity as a promising therapeutic strategy.

Keyword:     Hypoglycemic activity microparticles Physalis peruviana calyces rutin.


Echeverry SM, Valderrama IH, Costa GM, Ospina-Giraldo LF, Aragón DM. Development and optimization of microparticles containing a hypoglycemic fraction of calyces from Physalis peruviana. J App Pharm Sci, 2018; 8(05): 010-018.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

HTML Full Text


Article Metrics

521 Absract views 15 PDF Downloads 536 Total views

   Abstract      Pdf Download

Related Search

By author names

Citiaion Alert By Google Scholar

Name Required
Email Required Invalid Email Address

Comment required