Short Communication | Volume: 8, Issue: 4, April, 2018

Uranium-induced Cytotoxicity in HEK 293T Cells is reduced by a β-glucan type Exopolysaccharide produced by Enterobacter sp. YG4

K. K. Nagaraj,  A. B. Arun,  P. D. Rekha   
K. K. Nagaraj, A. B. Arun, P. D. Rekha

Yenepoya Research Centre, Yenepoya University, Deralakatte - 575018, Mangalore, Karnataka, India.

Open Access   

Published:  Apr 29, 2018

DOI: 10.7324/JAPS.2018.8425
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Abstract

Uranium-induced nephrotoxicity is a major health concern and countering it is essential. In this regard; a β-glucan type exopolysaccharide produced by Enterobacter sp. YG4 was tested for its capacity to reduce the uranyl nitrate-induced cytotoxicity in Human embryonic kidney cell line (HEK 293T). This exopolysaccharide at 0.5 mg/mL concentration was able to remove 80.94% of uranyl ions from its aqueous solution. Experiments with HEK 293T cells showed that the exposure to 0.05 mg/mL uranyl nitrate resulted in 22.13% cytotoxicity and treatment with YG4 exopolysaccharide could reduce the cytotoxicity of uranyl nitrate significantly. These results highlight the potential of this exopolysaccharide in counteracting the nephrotoxic effects of uranium.


Keyword:     Uranium Nephrotoxicity Exopolysaccharideβ-glucan.

Citation:

Nagaraj KK, Arun AB, Rekha PD. Uranium-induced Cytotoxicity in HEK 293T Cells is reduced by a β-glucan type Exopolysaccharide produced by Enterobacter sp. YG4. J App Pharm Sci, 2018; 8(04): 171-173.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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