Short Communication | Volume: 8, Issue: 4, April, 2018

Uranium-induced Cytotoxicity in HEK 293T Cells is reduced by a β-glucan type Exopolysaccharide produced by Enterobacter sp. YG4

K. K. Nagaraj A. B. Arun P. D. Rekha   

Open Access   

Published:  Apr 29, 2018

DOI: 10.7324/JAPS.2018.8425
Abstract

Uranium-induced nephrotoxicity is a major health concern and countering it is essential. In this regard; a β-glucan type exopolysaccharide produced by Enterobacter sp. YG4 was tested for its capacity to reduce the uranyl nitrate-induced cytotoxicity in Human embryonic kidney cell line (HEK 293T). This exopolysaccharide at 0.5 mg/mL concentration was able to remove 80.94% of uranyl ions from its aqueous solution. Experiments with HEK 293T cells showed that the exposure to 0.05 mg/mL uranyl nitrate resulted in 22.13% cytotoxicity and treatment with YG4 exopolysaccharide could reduce the cytotoxicity of uranyl nitrate significantly. These results highlight the potential of this exopolysaccharide in counteracting the nephrotoxic effects of uranium.


Keyword:     Uranium Nephrotoxicity Exopolysaccharideβ-glucan.


Citation:

Nagaraj KK, Arun AB, Rekha PD. Uranium-induced Cytotoxicity in HEK 293T Cells is reduced by a β-glucan type Exopolysaccharide produced by Enterobacter sp. YG4. J App Pharm Sci, 2018; 8(04): 171-173.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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