Case Report | Volume: 8, Issue: 4, April, 2018

Atorvastatin-Induced Hepatotoxicity, Increased by Clopidogrel Stress on CYP450 Enzyme: Understanding the Mechanism through a Case

Sahithi Thotakura Ajit Singh Kanav Khera Sheetal Chauhan Tom Devasia   

Open Access   

Published:  Apr 29, 2018

DOI: 10.7324/JAPS.2018.8424
Abstract

Statins are widely used drugs for both primary and secondary prevention of various cardiovascular disorders. Cases have been reported on statin-induced hepatitis where the elevation of liver enzymes leads to hepatotoxicity. Here we present a patient with atorvastatin-induced hepatotoxicity and the mechanism accelerated by clopidogrel use. The drugs which are metabolized by CYP450 can increase the risk of hepatitis. CYP4503A4 enzyme metabolizes both atorvastatin and clopidogrel. In this case, clopidogrel has shown the synergistic effect which is responsible for the significant liver injury.


Keyword:     Hepatotoxicity Coronary artery disease Alanine aminotransferase Aspartate aminotransferase Medication non-compliance RUCAM Score.


Citation:

Thotakura S, Singh A, Khera K, Chauhan S, Devasia T. Atorvastatin-Induced Hepatotoxicity, Increased by Clopidogrel Stress on CYP450 Enzyme: Understanding the Mechanism through a Case. J App Pharm Sci, 2018; 8(04): 168-170.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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