Research Article | Volume: 8, Issue: 4, April, 2018

Antitumor Hybrid BT009K Modulates Inflammation Induced Neovascuaralization in Both Tumorigenic and Non-Tumorigenic Model System

Shamanth Neralagundi H.G. Zabiulla Shaukath Ara Khanum Manjunatha H. Prabhakar B.T.   

Open Access   

Published:  Apr 29, 2018

DOI: 10.7324/JAPS.2018.8421
Abstract

Cancer being one of the most dreadful diseases and inflammation in cancer is one of the emerged Hallmarks of cancer. Discovering new drugs with minimal side effects plays a vital role in drug development process for the treatment of cancer. As an approach antitumor hybrid of “Benzophenone coupled with diamide analog “BT009K” or N-(2-{2- [4-(4-bromo-benzoyl)-2-methyl-phenoxy]-acetylamino}-phenyl)-2-[2-methyl-4-(2-methyl-benzoyl)-phenoxy] was screened against different cell lines. Cytotoxic effect was found to be effective against EAC with prolonged effect. The in-vivo antitumor effect was observed in EAC ascites tumor model system with reduced peritoneal neovascularisation. Further histological examination with endothelial marker CD31 confirmed the angioregressive effect of BT009K. The results were additionally confirmed in a non-tumorigenic model like CAM and rat corneal angiogenesis assay indicating reduced microvessel density count by BT009K. Further BT009K induces the anti-invasive effect in EAC cells in-vitro which could be further developed into therapeutic potential.


Keyword:     Inflammation angiogenesis BT009K EAC MVD.


Citation:

Shamanth Neralagundi HG, Zabiulla, Khanum SA, Manjunatha H, Prabhakar BT. Antitumor Hybrid BT009K Modulates Inflammation Induced Neovascuaralization in Both Tumorigenic and Non-Tumorigenic Model System. J App Pharm Sci, 2018; 8(04): 143-149.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

HTML Full Text

Reference

Article Metrics

450 Absract views 17 PDF Downloads 467 Total views

   Abstract      Pdf Download

Related Search

By author names

Citiaion Alert By Google Scholar

Name Required
Email Required Invalid Email Address

Comment required