Research Article | Volume: 8, Issue: 4, April, 2018
Research Article | Volume: 8, Issue: 4, April, 2018
Cancer being one of the most dreadful diseases and inflammation in cancer is one of the emerged Hallmarks of cancer. Discovering new drugs with minimal side effects plays a vital role in drug development process for the treatment of cancer. As an approach antitumor hybrid of “Benzophenone coupled with diamide analog “BT009K” or N-(2-{2- [4-(4-bromo-benzoyl)-2-methyl-phenoxy]-acetylamino}-phenyl)-2-[2-methyl-4-(2-methyl-benzoyl)-phenoxy] was screened against different cell lines. Cytotoxic effect was found to be effective against EAC with prolonged effect. The in-vivo antitumor effect was observed in EAC ascites tumor model system with reduced peritoneal neovascularisation. Further histological examination with endothelial marker CD31 confirmed the angioregressive effect of BT009K. The results were additionally confirmed in a non-tumorigenic model like CAM and rat corneal angiogenesis assay indicating reduced microvessel density count by BT009K. Further BT009K induces the anti-invasive effect in EAC cells in-vitro which could be further developed into therapeutic potential.
Shamanth Neralagundi HG, Zabiulla, Khanum SA, Manjunatha H, Prabhakar BT. Antitumor Hybrid BT009K Modulates Inflammation Induced Neovascuaralization in Both Tumorigenic and Non-Tumorigenic Model System. J App Pharm Sci, 2018; 8(04): 143-149.
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