Research Article | Volume: 8, Issue: 4, April, 2018
Research Article | Volume: 8, Issue: 4, April, 2018
Objective: This study aimed to evaluate the effect of Andrographis paniculata tablet (AS201-01) in decreasing expression of Toll-Like Receptor-4 (TLR-4) and apoptosis index of placental tissue of Plasmodium berghei infected pregnant mice. Material and Methods: A total of 24 pregnant mice were divided into 4 groups, G1 was uninfected pregnant mice group, G2 was untreated Plasmodium berghei infected pregnant mice, G3 was P. berghei infected pregnant mice treated with AS201-01 tablet and G4 was P. berghei infected pregnant mice treated with dihydropiperaquine-phosphate (DHP) tablets. All mice were sacrifice at day 15th of pregnancy and the placenta was collected. The TLR-4 expression and apoptosis index were evaluated using immunohistochemistry assay. Results: The TLR-4 expression and apoptosis index on G3 was lower than G2 and showed a statistically significant difference (P = 0.00). The TLR-4 expression and apoptosis index of placental tissue in P. berghei infected pregnant mice which treated with AS201-01 tablet were decreased compared to untreated group and DHP tablet treated group as well. Conclusion: AS201-01 tablet containing ethyl acetate fraction of A. paniculata could decrease TLR-4 expression and apoptosis index of placental tissue in P. berghei infected pregnant mice.
Prasetyo B, Ratih DN, Yustinasari, Ilmi H, Tumewu L, Widyawaruyanti A. Treated Plasmodium berghei infected pregnant mice by Andrographis paniculata tablet (AS201- 01) decreasing the TLR-4 expression and apoptosis index of placental tissue. J App Pharm Sci, 2018; 8(04): 105-108.
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