Research Article | Volume: 8, Issue: 1, January, 2018

Study of Vasodilating and Regenerative Effect of the Gel with Nettle Juice intended for Telogen Effluvium Treatment

Fedorovska Maryana Ivanivna,  Polovko Natalia Petrivna,  Fedenko Svitlana Mykolaivna,  Antymys Olga Vasylivna   
Fedorovska Maryana Ivanivna1, Polovko Natalia Petrivna2, Fedenko Svitlana Mykolaivna1, Antymys Olga Vasylivna3

1Organization and Economics in Pharmacy and Drug Technology Department, Ivano-Frankivsk National Medical University, Ukraine.

2Pharmaceutical Technology of Drugs Department, National University of Pharmacy, Kharkiv c., Ukraine.

3Human Anatomy Department, Ivano-Frankivsk National Medical University, Ukraine.

Open Access   

Published:  Jan 28, 2018

DOI: 10.7324/JAPS.2018.8114
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Abstract

Telogen effluvium remains the most common diffuse hair loss in women which influences the quality of their life. Stinginag nettle leaves and stems contain a wide range of biologically active substances which stimulate the metab¬olism and trophic processes in hair follicle cells. The purpose of the research was to study the vasodilating effect and follicle-stimulating activity of the gel with nettle juice in rats under conditions of wool shedding induced by orally administered boric acid. Thus, conducted pharmacological studies indicated that the gel in comparison with the untreated animals accelerated the wool growth in rats, improved its quality by increasing the weight and reducing the percentage of dystrophic hairs. Histological studies confirmed that cutaneous application of the gel significantly dilated the vessels in the dermis reticular layer. The intensification of blood supply was confirmed by an increase in the number of mast cells and their active degranulation. Strengthening of blood circulation caused the increase of the hair follicle quantity in the active anagen phase.


Keyword:     Telogen effluvium gel with nettle juice vasodilating effect follicle-stimulating activity.

Citation:

Ivanivna FM, Petrivna PN, Mykolaivna FS, Vasylivna AO. Study of Vasodilating and Regenerative Effect of the Gel with Nettle Juice intended for Telogen Effluvium Treatment. J App Pharm Sci, 2018; 8 (01): 093-097.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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