Research Article | Volume: 8, Issue: 1, January, 2018

Development and optimization of in-situ forming microparticles for long term controlled delivery of deslorelin acetate

Deepak N. Kapoor Om Prakash Katare Hemlata Kaurav Sanju Dhawan   

Open Access   

Published:  Jan 28, 2018

DOI: 10.7324/JAPS.2018.8110
Abstract

Deslorelin is a nonapeptide analogue of the natural gonadotropin releasing hormone or luteinizing hormone releasing hormone used to treat prostate cancer, endometriosis and uterine fibroids. In-situ forming microparticles were developed for deslorelin using smart, biodegradable polymer i.e. PLGA. Response surface, I-optimal design were used to design, formulate and characterize different formulations of deslorelin. To determine the optimized formulation, numerical and graphical optimization techniques were employed. The resulting optimized formulation was evaluated for other physicochemical parameters viz., rheology, particle size distribution, surface morphology of the particles, peptide conformation stability in the formulation and stability study at different environmental conditions. It was concluded that the optimized deslorelin acetate ISFM formulation effectively extended the peptide release for 30 days while maintaining its conformational stability during the period of study. The optimized ISFM formulation was found to be stable at 5°C ± 2°C and 25°C ± 2°C during 6 months stability studies.


Keyword:     PLGA Implants Optimal Design Peptide and Protein Delivery.


Citation:

Kapoor DN, Katare OP, Kaurav H, Dhawan S. Development and optimization of in-situ forming microparticles for long term controlled delivery of deslorelin acetate. J App Pharm Sci, 2018; 8 (01): 59-72.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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