Research Article | Volume: 8, Issue: 1, January, 2018

The Anti-dyslipidemic Effects of Milled Root Bark Ethanolic Extract of Capparis erythrocarpus in Sprague-Dawley Rats: Implications for Obesity and Cardiovascular Diseases

P. Saka,  K. E. Osafo,  S. Antwi,  O. N. K. Martey,  O. Quasie,  M. Antwi-Adjei,  J. Asiedu-Larbi,  N. K. Takyi,  K. N Donkor,  L. K. N. Okine   
P. Saka1, K. E. Osafo1, S. Antwi2, O. N. K. Martey2, O. Quasie2, M. Antwi-Adjei3, J. Asiedu-Larbi2, N. K. Takyi2, K. N Donkor2, L. K. N. Okine1

1Department of Biochemistry, Cell & Molecular Biology, University of Ghana, Legon, Accra, Ghana.

2Department of Pharmacology/Toxicology, Centre for Plant Medicine Research, Mampong-Akuapem, Ghana.

3Department of Pharmacology, School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana.

Open Access   

Published:  Jan 28, 2018

DOI: 10.7324/JAPS.2018.8101
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Abstract

Dyslipidaemia is a major risk factor of the onset of cardiovascular disease and obesity. Sirappac, the milled root bark of C. erythrocarpus has been reported to significantly reduce body weight and sizes of Sprague-Dawley rats with possible effects on the alteration of lipid metabolism. The present study was thus, aimed at determining the effects of sirappac on the body weight, food intake, serum lipid levels and blood pressures in rats. Male adult Sprague-Dawley rats were treated with sirappac at doses of 20, 100 and 200 mg/kg for a period of three months. Rats body weight and feed intake values were recorded daily. Serum triglycerides (TG), total cholesterol (TC), high density lipoprotein-cholesterol (HDLC), low density lipoprotein-cholesterol (LDLC) and leptin levels were determined monthly throughout the study period. At the end of the treatment period, there were significant (p<0.05) dose-dependent reductions in body weight, food intake, serum levels of TC, LDLC, TG and serum leptin. However, the levels of HDLC increased significantly (p<0.05) over the study period. Sirappac also significantly (p<0.05) reduced rat systolic blood pressure without effect on the diastolic blood pressure. The results indicate that sirappac exerts anti-lipidaemic effects and could be indicated in management of cardiovascular diseases, whilst preventing obesity by reducing feed intake and the rate of increase in body weight in Sprague-Dawley rats.


Keyword:     Dyslipidaemia cardiovascular disease obesity C. erythrocarpus.

Citation:

Saka P, Osafo KE, Antwi S, Martey ONK, Quasie O, Antwi-Adjei M, Asiedu-Larbi J, Takyi NK, Donkor KN, Okine LKN. The Anti-dyslipidemic Effects of Milled Root Bark Ethanolic Extract of C. erythrocarpus in Sprague-Dawley Rats: Implications for Obesity and Cardiovascular Diseases. J App Pharm Sci, 2018; 8(01): 001-008.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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