Research Article | Volume: 7, Issue: 12, December, 2017

Formation and Characterization of Sulfamethoxazole-Trimethoprim Cocrystal by Milling Process

Erizal Zaini Yeyet C. Sumirtapura Auzal Halim Lili Fitriani Sundani N. Soewandhi   

Open Access   

Published:  Dec 30, 2017

DOI: 10.7324/JAPS.2017.71224
Abstract

The purpose of this study was to describe and characterize co-crystal formation of sulfamethoxazole and trimethoprim. The co-crystal formation was carried out by solid state milling process. Co-crystal by solution co-crystallization and physical mixture were also prepared as a comparison. The potential co-crystalline phase was characterized by powder X-ray Diffraction (PXRD), thermal analysis differential scanning calorimetry (DSC), scanning electron microscope (SEM), and Fourier transform Infrared (FT-IR) spectroscopy. Effect of milling time on formation of co-crystal sulfamethoxazole and trimethoprim was investigated by DSC and PXRD analysis. The study showed that the milling process of sulfamethoxazole and trimethoprim in equimolar yielded the co-crystal. Intact co-crystal was obtained by solution co-crystallization with methanol. Prolongation of milling time accelerated the formation of co-crystal. Physical characterization showed that sulfamethoxazole and trimethoprim co-crystal demonstrated a unique powder X-ray diffraction, thermal and spectroscopic properties. The study concludes that the milling process induces equimolar co-crystal formation between sulfamethoxazole and trimethoprim. The transformation to co-crystalline phase is affected by milling time.


Keyword:     Co-crystal trimethoprim sulfamethoxazole milling process.


Citation:

Zaini E, Sumirtapura YC, Halim A, Fitriani L, Soewandhi SN. Formation and Characterization of Sulfamethoxazole-Trimethoprim Cocrystal by Milling Process. J App Pharm Sci, 2017; 7 (12): 169- 173.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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