Research Article | Volume: 7, Issue: 12, December, 2017

Formation and Characterization of Sulfamethoxazole-Trimethoprim Cocrystal by Milling Process

Erizal Zaini Yeyet C. Sumirtapura Auzal Halim Lili Fitriani Sundani N. Soewandhi   

Open Access   

Published:  Dec 30, 2017

DOI: 10.7324/JAPS.2017.71224

The purpose of this study was to describe and characterize co-crystal formation of sulfamethoxazole and trimethoprim. The co-crystal formation was carried out by solid state milling process. Co-crystal by solution co-crystallization and physical mixture were also prepared as a comparison. The potential co-crystalline phase was characterized by powder X-ray Diffraction (PXRD), thermal analysis differential scanning calorimetry (DSC), scanning electron microscope (SEM), and Fourier transform Infrared (FT-IR) spectroscopy. Effect of milling time on formation of co-crystal sulfamethoxazole and trimethoprim was investigated by DSC and PXRD analysis. The study showed that the milling process of sulfamethoxazole and trimethoprim in equimolar yielded the co-crystal. Intact co-crystal was obtained by solution co-crystallization with methanol. Prolongation of milling time accelerated the formation of co-crystal. Physical characterization showed that sulfamethoxazole and trimethoprim co-crystal demonstrated a unique powder X-ray diffraction, thermal and spectroscopic properties. The study concludes that the milling process induces equimolar co-crystal formation between sulfamethoxazole and trimethoprim. The transformation to co-crystalline phase is affected by milling time.

Keyword:     Co-crystal trimethoprim sulfamethoxazole milling process.


Zaini E, Sumirtapura YC, Halim A, Fitriani L, Soewandhi SN. Formation and Characterization of Sulfamethoxazole-Trimethoprim Cocrystal by Milling Process. J App Pharm Sci, 2017; 7 (12): 169- 173.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

HTML Full Text


Article Metrics
110 Absract views 147 Absract Downloads 257 Total
Related Search

By author names