Research Article | Volume: 7, Issue: 11, November, 2017

Assessment of Quality of Life and Severity of Itching Pre and Post Doxepin Therapy in Dialysis Patients with Pruritus

Kousalya Prabahar Danda Anusha Soundararajan Periasamy Boddu Sri Venkata Rishitha Anand Ramanathan Dasari Anudeep   

Open Access   

Published:  Nov 30, 2017

DOI: 10.7324/JAPS.2017.71118

Objective: Chronic kidney disease (CKD)-associated pruritus is a significant clinical symptom affecting more than 50% of patients on hemodialysis. The main aim of this study was to assess the effects of doxepin treatment on the quality of life of pruritic patients.

Material and methods: This prospective-interventional study was carried out for a period of 6 months in dialysis unit of Department of Nephrology in a tertiary care teaching hospital, Chennai. Both inpatients and outpatients of both sexes ≥ 18 years on hemodialysis or peritoneal dialysis for more than 3 months with pruritus were included for the study. A total number of 39 dialysis patients with pruritus were recruited for the study. Patients were evaluated at the beginning of the study and at the end of 2 weeks of each study period. The severity, duration, degree, direction, disability and distribution of itch were evaluated using 5D- pruritus scale. The quality of life of patients was assessed using DLQI questionnaire (Dermatology Life Quality Index).

Results: There was an improvement in quality of life of patients with pruritus after doxepin therapy.

Conclusion: Doxepin is a better therapy for itching and improving the quality of life in dialysis patients. Clinicians should enquire about skin irritation and itching during consultations since patients may be reluctant to admit to these symptoms due to embarrassment.

Keyword:     Itch pruritus doxepin.


Prabahar K, Danda A, Periasamy S, Boddu R, Ramanathan A, Dasari A. Assessment of Quality Of Life and Severity of Itching Pre and Post Doxepin Therapy in Dialysis Patients with Pruritus. J App Pharm Sci, 2017; 7 (11): 119-125.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

HTML Full Text


Article Metrics
401 Views 19 Downloads 420 Total



Related Search

By author names