Research Article | Volume: 7, Issue: 11, November, 2017

New approaches in protecting against atherosclerosis in experimental model of postmenopause

Dalia Medhat Mona A. El-Bana Magdi N. Ashour Ehsan Badawy Yasser Diab Jihan Hussein   

Open Access   

Published:  Nov 30, 2017

DOI: 10.7324/JAPS.2017.71114
Abstract

This work is aimed to evaluate the ability of Myrtus communis leaves extract in attenuating endothelial dysfunction as well as risk of atherosclerosis in ovariectomized rats as a common model of postmenopause. Total 60 female albino rats, weighing 180 g were used and assigned to four groups (sham, sham and Myrtus communis leaves extract, ovariectomized rats (OVX) and ovariectomized treated rats with Myrtus communis leaves extract). Plasma estrogen, lipid profile, asymmetric dimethylarginine (ADMA), von Willebrand factor (vWF), interleukin 1beta (IL-1β), Lipoxin A4 (LXA4), aortic oxidant and antioxidant in addition to erythrocyte membrane fatty acids were determined. OVX rats showed a significant increase in inflammatory and oxidant parameters while, Myrtus communis extract administration (100 mg/kg body weight) for two months attenuates these values in treated group. Myrtus communis leaves extract confirmed our idea in protecting from atherosclerosis and endothelial dysfunction in ovariectomized rats due to its high content of anti-oxidant and anti-inflammatory compounds in addition to its high content of ω-3 fatty acids.


Keyword:     Myrtus communis leaves extract ovariectomized rats estrogen lipoxin A4 fatty acids HPLC.


Citation:

Medhat D, El-Bana MA, Ashour MN, Badawy E, Diab Y, Hussein J. New approaches in protecting against atherosclerosis in experimental model of postmenopause. J App Pharm Sci, 2017; 7 (11): 090-096.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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