Research Article | Volume: 7, Issue: 10, October, 2017

Synthesis of Carboxymethyl Chitosan and its Rheological Behaviour in Pharmaceutical and Cosmetic Emulsions

Desislava Tzaneva,  Apostol Simitchiev,  Nadezhda Petkova,  Ventzislav Nenov,  Albena Stoyanova,  Panteley Denev   
Desislava Tzaneva1, Apostol Simitchiev2, Nadezhda Petkova1, Ventzislav Nenov2, Albena Stoyanova3, Panteley Denev1

1Department of Organic Chemistry, University of Food Technologies, 26 Maritza Blvd., 4002, Plovdiv, Bulgaria.

2Department of Machinery for Food Industry, Technical Faculty, University of Food Technologies, 26 Maritza Blvd., 4002, Plovdiv, Bulgaria.

3Department of Essential Oils, University of Food Technologies, 26 Maritza Blvd., 4002, Plovdiv, Bulgaria.

Open Access   

Published:  Oct 30, 2017

DOI: 10.7324/JAPS.2017.71010
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Abstract

The aim of the current study was synthesis and characterization of CMC and further evaluation of its emulsion stabilizing properties for preparation of pharmaceutical and cosmetic emulsions. Carboxymethyl chitosan (CMC) with high degree of substitution (50 %) has been synthesized and further characterization of resulting product by FTIR, NMR spectroscopy and thermal analysis (TGA/DTA) was carried out. CMC was also characterized as water soluble polymer with ability to give solutions with high viscosity. Rheological behavior of cosmetic emulsions prepared with 0.3 and 0.5 % CMC was investigated. Thermodynamic parameters of emulsions, Gibbs free energies, enthalpies and entropies have been calculated. The current study demonstrated use of CMC as stabilizer of emulsions with potential application in pharmaceutical and cosmetic oil/water emulsions.


Keyword:     Carboxymethyl chitosan FTIR spectroscopy NMR spectra TGA emulsions rheological and thermodynamic properties.

Citation:

Tzaneva D, Simitchiev A, Petkova N, Nenov V, Stoyanova A, Denev P. Synthesis of Carboxymethyl Chitosan and its Rheological Behaviour in Pharmaceutical and Cosmetic Emulsions. J App Pharm Sci, 2017; 7 (10): 070-078.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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