Research Article | Volume: 7, Issue: 10, October, 2017

Synthetic and Systems Biology Approach towards Designing Metabolic Bypass and Identifying Novel Enzymes for Cholesterol Lowering Drug Precursor (BTO) Biosynthesis from Crude Glycerol

Dipankar Ghosh   

Open Access   

Published:  Oct 30, 2017

DOI: 10.7324/JAPS.2017.71007
Abstract

1, 2, 4-Butanetriol (BTO) is a potential precursor of Cholesterol Lowering Drugs. BTO production is predominantly dependent on chemical conversions at present. Biological route for BTO biosynthesis suffers due to multiple issues like unavailability of efficient biosynthetic pathways, inefficient enzymes, usage of expensive edible feedstock and unavailability of suitable chassis host strains. These issues practically restrict its large scale bio-industrial productions considering lower molar yield, titer and productivity of BTO via biosynthetic route. The main aim of this study is to find out efficient novel biosynthetic pathways which can convert non-edible feedstock (crude glycerol from biodiesel waste) towards BTO biosynthesis. The second aim of this study is to identify putative non-natural enzyme classes predicted to be involved in these biosynthetic pathways. Future perspective will be to functionalize these pathways towards In-vivo validation within suitable metabolically engineered microorganisms for improving BTO biosynthesis.


Keyword:     1 2 4-Butanetriol Cholesterol Lowering Drug Biodiesel Waste Crude Glycerol Chassis Strain Biosynthetic Pathway.


Citation:

Ghosh D. Synthetic and Systems Biology Approach towards Designing Metabolic Bypass and Identifying Novel Enzymes for Cholesterol Lowering Drug Precursor (BTO) Biosynthesis from Crude Glycerol. J App Pharm Sci, 2017; 7 (10): 048-054.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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