Review Article | Volume: 7, Issue: 9, September, 2017

Current and Emerging Therapies for the Management of Diabetic Retinopathy

Manodhini ElakkiyaKousalya SelvarajGowthamarajan Kuppuswamy   

Open Access   

Published:  Sep 30, 2017

DOI: 10.7324/JAPS.2017.70933
Abstract

Diabetes Mellitus (DM) has many complications, in which Diabetic Retinopathy (DR) is the major one. Blindness among working age people was due to DR. Retinal angiogenesis and retinal vascular permeability is the pathogenesis behind vision loss. Polyol pathway, protein kinase C (PKC) activation, renin angiotensin-aldosterone system (RAAS), oxidative stress etc are the pathophysiological pathways which are discussed in this review for better understanding. PKC inhibitors, anti-inflammatory agents, RAAS blockers, anti-vascular Endothelial growth factor (VEGF) agents, antioxidants and fibrates which are the used for the better treatment for DR is also elaborated in this review.


Keyword:     Diabetic retinopathyPathogenesiscurrent therapiesemerging therapiesOcular neovascularisation.


Citation:

Elakkiya M, Selvaraj K, Kuppuswamy G. Current and Emerging Therapies for the Management of Diabetic Retinopathy. J App Pharm Sci, 2017; 7 (09): 243-251.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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