Research Article | Volume: 7, Issue: 9, September, 2017

Pharmacological evaluation of endophytic Penicillium pimiteouiense SGS isolated from Simarouba glauca DC

Salini Dinesh Devi Soorya Narayana Sasikumar Bala Girija Lakshmipriya V. Panicker Pooja Vinod Kumar Sruthy Preetha Shaima Santhilal Sarma   

Open Access   

Published:  Sep 30, 2017

DOI: 10.7324/JAPS.2017.70919

Medicinal plants are recently being recognized as resources of endophytes with interesting bioactive compounds. In the present study, pharmacological properties of the endophytic fungus Penicillium pimiteouiense SGS isolated from the medicinal plant Simarouba glauca DC were evaluated. Endophytes were isolated using surface sterilization procedure. The crude extract of cultured fungus was prepared in ethyl acetate and was evaluated for antimicrobial, antioxidant and anti hyperglycaemic activities. Phytochemical composition of the crude extract was also studied by standard qualitative assays. The extract of P. pimiteouiense SGS was found to have antimicrobial and antioxidant properties. Anti hyper glycaemic activity was also revealed by its inhibitory activities on alpha amylase and alpha glucosidase enzymes. Qualitative phyto chemical analysis of the crude extract showed presence of flavanoids, triterpenes, alkaloids and carbohydrates. The medicinal plant S. glauca needs to be explored further as a resource of rare endophytes with bio active compounds.

Keyword:     Alpha amylase alpha glucosidase antioxidant activity endophytes phytochemicals.


Dinesh S, Sasikumar DSN, Girija B, Panicker LV, Kumar PV, Preetha S, Sarma SS. Pharmacological evaluation of endophytic Penicillium pimiteouiense SGS isolated from Simarouba glauca DC. J App Pharm Sci, 2017; 7 (09): 142-147.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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