Research Article | Volume: 7, Issue: 9, September, 2017

Modulation of Pimpinella tirupatiensis aqueous extract on Brain Mitochondrial Enzymes in STZ induced diabetic rats

D. Veera Nagendra Kumar K. R. Shanmugam Ch. Ramakrishna G. Venkata Subbaiah K. Sathyavelu Reddy   

Open Access   

Published:  Sep 30, 2017

DOI: 10.7324/JAPS.2017.70910
Abstract

The objective of the present study was to investigate the role of Pimpinella tirupatiensis (Pt) aqueous extract on brain mitochondrial enzymes in Streptozotocin (STZ) induced diabetic rats. Adult male wistar strain rats were divided into five groups as NC (normal control), Pt. (Pimpinella treatment), DC (Diabetic control), D+Pt (Diabetic+ Pimpinella treatment), D+Gli (Diabetic + Glibenclamide treatment). Treatment was given as per the experimental protocol for 30days. Succinate dehydrogenase (SDH), glucose-6-phosphate dehydrogenase (G6PD), malate dehydrogenase (MDH),and glutamate dehydrogenase (GDH), and lactae dehydrogenase (LDH) enzymes activities were assayed in the brain tissue. In diabetic rats, we observed decreased activities of SDH, G6PDH, MDH, GDH and increased LDH activity. However with the Pimpinella tirupatiensis treatment mitochondrial enzymes activities were came back to normalcy. Our results suggest that the Pt supplementation modulates the mitochondrial enzymes activities in diabetic rats.


Keyword:     Diabetes Pimpinella tirupatiensis Mitochondrial enzymes Brain Rats.


Citation:

Nagendra Kumar DV, Shanmugam KR, Ramakrishna Ch., Subbaiah GV, Reddy KS. Modulation of Pimpinella tirupatiensis aqueous extract on Brain Mitochondrial Enzymes in STZ induced diabetic rats. J App Pharm Sci, 2017; 7 (09): 076-080.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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