Research Article | Volume: 7, Issue: 9, September, 2017

Synthesis, Docking Studies and Anticancer Activity of New Substituted Pyrimidine and Triazolopyrimidine Glycosides

Wael A. El-Sayed Ashraf M. Mohamed Hemat S. Khalaf Dina S. EL-Kady May Al-Manawaty   

Open Access   

Published:  Sep 30, 2017

DOI: 10.7324/JAPS.2017.70901

New substituted pyrimidine and triazolopyrimidine derivatives were synthesized. The N3-glycosides of both heterocyclic systems and acyclic oxygenated alkyl derivatives were also prepared. The anticancer activity against human prostatic adenocarcinoma (PC3), human colorectal carcinoma (HCT116) and human breast adenocarcinoma (MCF7) cell lines in addition to their effect on human normal retinal pigmented epithelial cell line (RPE1) was studied. Furthermore, the docking studies revealed good binding affinities for compounds 7, 8, 10 and 12. The results showed the effect of N3-substitution in the pyrimidine ring on the activity of synthesized compounds.

Keyword:     PyrimidinetriazolopyrimidineglycosidesEnzyme Dockinganticancer activity.


El-Sayed WA, Mohamed AM, Khalaf HS, EL-Kady DS, AlManawaty M. Synthesis and Anticancer Activity of New Substituted Pyrimidine and Triazolopyrimidine Glycosides. J App Pharm Sci, 2017; 7 (09): 001-011.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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