Research Article | Volume: 7, Issue: 8, August, 2017

Effect of Poikilacanthus glandulosus (Nees) Ariza branches and gallic acid against viability of Echinococcus ortleppi protoscoleces

Thiele Faccim de Brum Roberta da Silva Jesus Bianca Vargas Belke Danieli Urach Monteiro Natalia Jank Mossmann Mariana Pianaa Sílvio Terra Stefanello Félix Alexandre Antunes Soares Mário Luiz De La Rue and Liliane de Freitas Bauermann   

Open Access   

Published:  Aug 30, 2017

DOI: 10.7324/JAPS.2017.70817
Abstract

The aim of this study was to assess the antioxidant capacity and to evaluate effect of P. glandulosus on the viability of protoscoleces of Echinococcus spp. as well as determine the possible substance in charge for this action. Echinococcus ortleppi protoscoleces were exposed front of the crude extract and butanol fraction and gallic acid at different times.Phytochemical study revealed the presence of triterpenoids, steroids, coumarins, catechins, phenols, anthocyanins, anthocyanidins and cardioactiveheterosides. The highest polyphenol and flavonoids content was found in the ethyl acetate(151.34±1.71mg/g) and dichlorometane (123.30±1.46mg/g), respectively. For assays with DPPH the ethyl acetate fraction was highlighted (IC5095.48±0.35 µg/mL) and the dichlorometane fraction significantly reduced lipid peroxidation (IC50 135.75±2.39 µg/mL) and also the oxidation of DCFH (15.6 µg/mL). The crude extract, butanol fraction and gallic acid showed scolicidal action of 100% at 15, 10 and 15 minutes, respectively.




Citation:

Brum TFD, Jesus RDS, Belke BV, Monteiro DU, Mossmann NJ, Piana M, Stefanello ST, Soares FSAA, Rue MLDLR, Bauermann LDF. Effect of Poikil acanthus glandulosus (Nees) Arizabranches and gallic acid against viability of Echinococcus ortleppi protoscoleces. J App Pharm Sci, 2017; 7 (08): 123-130.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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