Research Article | Volume: 7, Issue: 7, July, 2017

Oil of Mesua ferrea L. Seed as a Promising Pharmaceutical Excipient in Lipid Based Nanoformulation

Tapash Chakraborty Malay K. Das   

Open Access   

Published:  Jul 30, 2017

DOI: 10.7324/JAPS.2017.70721
Abstract

This paper reports the studies on the application of Mesua ferrea L. (nahor) seed oil as a safe pharmaceutical excipient. The nahor seed oil was extracted by hot continuous percolation process using a soxhelt apparatus and analyzed by TLC and LC-MS. The safety profile of the oil was studied by acute toxicity study in a rat model and MTT assay with mouse brain endothelial cells (bEnd.3). The compatibility of the oil with other excipients was studied by DSC and FT-IR analysis.TLC and LC-MS study suggest the oil is composed of fatty acids similar to other USP grade oils. The acute toxicity study and MTT assay suggest the safe use of the nahor oil at the cellular level in the living system. DSC and FT-IR study confirm the compatibility of the oil with the general components of the lipid nanoparticles. This work provides a new dimension to M. ferrea L. seed oil for its safe use in the pharmaceutical formulation.


Keyword:     Acute toxicity Biocompatibility Messua ferrea L. Nahor seed oil NLC Pharmaceutical excipient.


Citation:

Chakraborty T, Das MK. Oil of Mesua ferrea L. Seed as a Promising Pharmaceutical Excipient in Lipid Based Nanoformulation. J App Pharm Sci, 2017; 7 (07): 133-141.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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