Published:  Jul 30, 2017DOI: 10.7324/JAPS.2017.70714
Pheromone Receptor Pre-A (PRP-A) is a G Protein-coupled receptor (G-PCR protein with seven transmembrane helices) in Aspergillus flavus, a filamentous fungus known for its aflatoxin production, germination and quorum sensing. It causes an aspergillosis in human beings and domestic animals. With an aim to find a better inhibitor against biosynthesis of aflatoxin, the integral protein structure was effectively engineered, designed, screening against various antifungal compound databases. The LibDock protein-ligand interaction of DSv3.5 study suggests that blasticidin S, pipernonaline and piperin, inhibit PRP-A protein with highest binding affinity. The amino acids frequently involved in binding with the ligand blasticidin S of O2 and H33 and H234 at Arg 400 and Tyr 394 respectively. Our in silico prediction may lead to establish better therapeutic approaches for the treatment against aspergillosis.
Kumar M, Rana S, Kumar H, Kumar P, Dikhit MR, Monsuri R, Kumar J, Sahoo GC. Computational, structural and functional aspects of hypothetical protein of Aspergillus flavus Pheromone Receptor Pre-A (PRP-A). J App Pharm Sci, 2017; 7 (07): 089-097.
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