Research Article | Volume: 7, Issue: 7, July, 2017

Comparative Study of Genotoxicity of Silver and Gold Nanoparticles Prepared by the Electric Spark Dispersion Method

Evgenii Plotnikov,  Sergey Zhuravkov,  Andrew Gapeyev,  Vladimir Plotnikov,  Irina Martemianova,  Dmitrii Martemianov   
Evgenii Plotnikov1, Sergey Zhuravkov1, Andrew Gapeyev2, Vladimir Plotnikov3, Irina Martemianova1, Dmitrii Martemianov1

1Tomsk Polytechnic University, Lenin Av. 30, Tomsk, Russia.

2Institute of Cell Biophysics of Russian Acad. Sci., Pushchino, Russia.

3Polytech ltd, Asinovskaya str. 7, Tomsk, Russia.

Open Access   

Published:  Jul 30, 2017

DOI: 10.7324/JAPS.2017.70705
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Abstract

Objective: There is plenty of information dedicated to nanomaterial toxicity, but it is often contradictory. This work presents results of the comparative investigation of silver and gold nanoparticles genotoxicity and genotoxic effect of water medium after the spark dispersion process.

Material and methods: The nanoparticles were produced in water by the modified energy-efficient electric spark dispersion method. The comet assay, transmission electron microscopy, DLS spectroscopy and thermal desorption of nitrogen (BET method) were used for the investigation.

Results: The silver nanoparticles showed a genotoxic effect which appeared at concentration of 0.03 mg/ml and above. The application of gold nanoparticles did not lead to a significant DNA damage at concentrations range of 0.01 - 0.03 mg/ml. However, a notable level of genotoxicity was observed at concentrations of gold nanoparticles about 0.1 mg/ml. Supernatant water medium (with trace of Au and Ag metals) following the spark dispersion process showed no genotoxic action.

Conclusion: Accordingly, the testing of the nanoparticles produced by the electric spark dispersion in water revealed more expressed genotoxic effect of silver nanoparticles in comparison with the gold ones.


Keyword:     Genotoxicity silver nanoparticles electric spark dispersion gold nanoparticles comet assay leukocytes.

Citation:

Plotnikov E, Zhuravkov S, Gapeyev A, Plotnikov V, Martemianova I, Martemianov D. Comparative Study of Genotoxicity of Silver and Gold Nanoparticles Prepared by the Electric Spark Dispersion Method. J App Pharm Sci, 2017; 7 (07): 035-039.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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