Review Article | Volume: 7, Issue: 5, May, 2017

Mucoadhesive Polymers and Their Mode of Action: A Recent Update

Bappaditya Chatterjee Nursazreen Amalina Pinaki Sengupta Uttam Kumar Mandal   

Open Access   

Published:  May 30, 2017

DOI: 10.7324/JAPS.2017.70533
Abstract

The potential of mucoadhesive delivery system for sustained delivery of drug has been established few decades back. Different polymeric systems such as single or combined, substituted, conjugated, pre-activated polymer (s) etc. are used to develop such delivery platform. To explain the mucoadhesion mechanism, several possible theories namely electronic theory, adsorption theory, wetting theory, diffusion theory, fraction theory and mechanical theory have been proposed. But none of these theories alone can explain the mechanism of mucoadhesion. Various mechanisms of mucoadhesion or bioadhesion between polymer and mucin such as H bonding, electrostatic interactions, di-sulfide linkage, van Der Waals attraction etc have been evidenced. Researches are focused to enrich such interaction between the mucous layer and the delivery platform by modifying the system. Wide varieties of polymers such as cationic, anionic, non-ionic, thiolated polymers etc have been used to design and develop mucoadhesive drug delivery system. Therefore reviewing and analyzing the mucoadhesive polymeric system and their mechanism of action is still relevant and necessary. The aim of this current review is to highlight the polymers which are being used under recent scientific researches with emphasis on their mechanism of mucoadhesion. The result of this critique will assist researchers to screen the mucoadhesive polymers for their designated purpose.


Keyword:     Mucoadhesive drug delivery system Bioadhesion Sustained delivery Polymers Mucoadhesison mechanism


Citation:

Chatterjee B, Amalina N, Sengupta P, Mandal UK. Mucoadhesive Polymers and Their Mode of Action: A Recent Update. J App Pharm Sci, 2017; 7 (05): 195-203.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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