Research Article | Volume: 7, Issue: 5, May, 2017

Optimization of artesunate delivery by formulation in a delayed release prosopis hemicellulose matrix

Emmanuel O. Olorunsola Musiliu O. Adedokun Partap G. Bhatia Babajide A. Tytler Michael U. Adikwu   

Open Access   

Published:  May 30, 2017

DOI: 10.7324/JAPS.2017.70525

This study was aimed at formulating artesunate in a hemicellulose – based matrix for an optimized delivery. Artesunate (ATS) tablets containing varying concentrations of prosopis gum (PRG) in the range of 1 to 4% w/w were formulated. Tablets containing 3% w/w standard acacia gum (ACG) were also formulated to serve as a control. Tablet density, tensile strength, swelling index and swelling time were determined. Drug release and permeation were also studied. There were no significant differences in tablet density and in swelling index but tensile strength and swelling time increased significantly with increase in concentration of PRG. Rate of drug release from tablets containing 3% w/w ACG was faster than those containing same concentration of PRG. Tablets containing 4% w/w PRG brought forth cumulative drug release of 27.2%, 57.0% and 78.6% in 30 min, 60 min and 120 min respectively. All PRG batches brought forth complete drug permeation within 180 min. Prosopis gum at concentration of 4% w/w can delay the release of artesunate so that 57.0 to 78.6% of the drug is released at the gastric region while 21.4 to 43.0% is released at the intestinal region of the gastrointestinal tract for optimized delivery of the drug.

Keyword:     Artesunate delayed release optimized delivery hemicellulose prosopis gum.


Olorunsola EO, Adedokun MO, Bhatia PG, Tytler BA, Adikwu MU. Optimization of artesunate delivery by formulation in a delayed release prosopis hemicellulose matrix. J App Pharm Sci, 2017; 7 (05): 142-146.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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