Published:  May 30, 2017DOI: 10.7324/JAPS.2017.70525
This study was aimed at formulating artesunate in a hemicellulose – based matrix for an optimized delivery. Artesunate (ATS) tablets containing varying concentrations of prosopis gum (PRG) in the range of 1 to 4% w/w were formulated. Tablets containing 3% w/w standard acacia gum (ACG) were also formulated to serve as a control. Tablet density, tensile strength, swelling index and swelling time were determined. Drug release and permeation were also studied. There were no significant differences in tablet density and in swelling index but tensile strength and swelling time increased significantly with increase in concentration of PRG. Rate of drug release from tablets containing 3% w/w ACG was faster than those containing same concentration of PRG. Tablets containing 4% w/w PRG brought forth cumulative drug release of 27.2%, 57.0% and 78.6% in 30 min, 60 min and 120 min respectively. All PRG batches brought forth complete drug permeation within 180 min. Prosopis gum at concentration of 4% w/w can delay the release of artesunate so that 57.0 to 78.6% of the drug is released at the gastric region while 21.4 to 43.0% is released at the intestinal region of the gastrointestinal tract for optimized delivery of the drug.
Olorunsola EO, Adedokun MO, Bhatia PG, Tytler BA, Adikwu MU. Optimization of artesunate delivery by formulation in a delayed release prosopis hemicellulose matrix. J App Pharm Sci, 2017; 7 (05): 142-146.
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