Poor adherence of chronic diseases treatment is a worldwide problem, in Ukraine as well. Improving adherence also enhances patients’ safety. Consequently, interventions that target adherence must be tailored to the particular illness-related demands experienced by the patient. The aim of the research was to determine the patient’s adherence level to pharmacotherapy through «face-to-face» interview 55 patients (visitors) in a pharmacy in Lviv (Ukraine). The methods of descriptive statistics have been used during the research results’ analyzes. The main 3 categories of factors of non-adherence to pharmacotherapy in Ukraine were conducted: 1) factors related to the patient (59.7%); 2) factors related with pharmacotherapy (26.9%); 3) socio-economic factors (13.4%). We established that the most common problems of non-adherence were: missed drugs dosage’s (40.1%), contravention duration pharmacotherapy (32.9%) and contravention of frequency of taking medicines (14.6%). We established that the level of adherence declines with the increase of number prescribed drugs (r= -0.33; R= -0.35; p <0.05), diseases of the patient (r= -0.27; R= -0.25; p<0.05) and the cost of medicines (r= -0.17; R= -0.19; p <0.05). However, the level of adherence does not depend on the age of the patient (r= -0.10; R= -0.12; p>0.05).