Research Article | Volume: 7, Issue : 4, April, 2017

Fibrinolysis parameters in the acute and post ischemic stroke patients

Tetiana Katrii Viktoria Shandyuk Natalia Raksha Tetiana Halenova Olexiy Shershnov Volodymyr Melnyk Olexiy Savchuk   

Open Access   

Published:  Apr 30, 2017

DOI: 10.7324/JAPS.2017.70413
Abstract

Analysis of fibrinolysis of the haemostasis system of the patients with acute ischemic stroke as well as one year past acute phase of ischemic stroke were performed. The significant inhibition of fibrinolytic potential of the post stroke patients were showed. The development of both pathological conditions accompanied by lengthening of time of the euhlobulin fraction lysis and FXIIa-dependent fibrinolysis. Moreover cardioembolic ischemic stroke were inherent more threatening performance. Lower activity of plasmonogen as well as α2-antiplasmin in blood plasma of the patients with atherothrombotic ischemic stroke was showed. Both tested pathological conditions were accompanied with abnormal concentrations of t-PA and PAI-1. Even one year past stroke attack the disorders in fibrinolysis still saved.


Keyword:     Ischemic stroke PAI-1 t-PA Plasminogen α2-antiplasmin FXII-dependent fibrinolysis Euglobulin lysis time.


Citation:

Katrii T, Shandyuk V, Raksha N, Halenova T, Shershnov O, Melnyk V, Savchuk O. Fibrinolysis parameters in the acute and post ischemic stroke patients. J App Pharm Sci, 2017; 7 (04): 096- 102.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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