Review Article | Volume: 7, Issue: 3, March, 2017

Relation between diabetes mellitus, thyroid hormones and caffeine

Luiz Augusto da Silva Jéssica Wouk Vinícius Müller Reis Weber Carlos Ricardo Maneck Malfatti Raul Osiecki   

Open Access   

Published:  Mar 30, 2017

DOI: 10.7324/JAPS.2017.70334

Diabetes mellitus (DM) has an important relation with thyroid hormones (TH) dysfunctions, and if analyzed accurately, may contribute to the diagnosis of clinical conditions such as hyperglycemia and insulin resistance (IR). Relevant studies are being made about the role of TH in mediating metabolic actions related to DM, acting in many glands and energetic subtracts regulator tissues. Some issues, such as the action of TH over the ionic regulation in the cells, altering actions in different paths; its role over the negative feedback by downregulations upon insulin action, but provoking an increase in β pancreatic cells proliferations, point out important directions to research. The mechanisms of action related to thyroid hormones and the insulinotropic action form a counterbalance, and if an imbalance occur (hyperthyroidism or hypothyroidism) it may be noted the presence of DM or IR. The interactions between TH, DM and caffeine are unknown aspects in the literature, which need a better attention and the development of experimental clinic studies to elucidate their mechanisms and clinical applications.

Keyword:     Insulin resistance insulin glucose metabolism.


Silva LA, Wouk J, Weber VMR, Malfatti CRM, Osiecki R. Relation between diabetes mellitus, thyroid hormones and caffeine. J App Pharm Sci, 2017; 7 (03): 212-216.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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