Published:  Mar 30, 2017DOI: 10.7324/JAPS.2017.70302
3-(1h-benzimidazol-2-yl)-1,2,2- trimethylcyclopentancarboxylic acid (C7070) is a novel synthetic imidazoline receptor agonist - potential antidiabetic agent. This study aimed to obtain the pharmacokinetic profiles in rats. Additionally, an HPLC MS/MS method was developed and validated to quantify C7070 in rat plasma. The pharmacokinetic profiles of intragastric and intravenous administration routes at singles doses of 50 mg/kg, were studied in rats. The elimination half-life of intravenously administered C7070 was approximately 154.1 min. The maximum plasma level of C7070 was reached approximately 170 min (2.8 h) after intragastric administration, with a Cmax value of 17.6 μg/mL and an AUC (o-t) value of 6964 μg*min-1/mL; the oral bioavailability was approximately 18%.
Aleksandr K, Tatyana A, Mikhail P, Mikhail K. Pharmacokinetics of a new imidazoline receptor agonist in rat plasma after intragastric and intravenous administration. J App Pharm Sci, 2017; 7 (03): 006-008.
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