Published:  Dec 28, 2016DOI: 10.7324/JAPS.2016.601208
Objectives: Diarrhoeal disease is often a leading source of mortality and morbidity, especially among children in developing countries causing a major healthcare problem. As per suggestion of WHO, treatment of diarrhoea with traditional medicine is the main focus of our present studies. The present study is designed to evaluate the anti-diarrhoeal activity of crude methanol extract of Urena sinuata L. (U. sinuata) and its fractions.
Methods: Crude methanol extracts are obtained by in vacue methods and its fractionating is done by Kupchan partitioning method. The anti-diarrhoeal activity is screened by castor oil-induced diarrhoea, castor oil-induced enteropooling and gastrointestinal motility test.
Results: The diarrheal severity was reduced significantly (P < 0.01) by ethyl acetate fraction by 37.01% whereas 44.78% inhibition was found for standard drug loperamide at 5 mg/kg. The two fractions namely hydro methanol, ethyl acetate and crude methanol extract also significantly (P < 0.01) reduced the intestinal volume in case of castor oil induced enteropooling.
Conclusion: It is concluded that, leaves of U. sinuata contains bioactive natural substances with anti-diarrhoeal properties. These attributes may give a justification for your use of U. sinuata in diarrhoea management by traditional healers.
NasirUddin MM, Zahan S, Islam A, Ahmed S, Mowla TE, Rahman MS, Emran TB. Evaluation of the anti-diarrheal activity of methanol extract and its fractions of Urena sinuata L. (Borss) leaves. J App Pharm Sci, 2016; 6 (12): 056-060.
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