Research Article | Volume: 6, Issue: 12, December, 2016

Interpenetrating Polymer Network Hydrogel Membranes of Karayagum and Sodium Alginate for Control Release of Flutamide Drug

Guruguntla Nagarjuna Palla Kumara Babu Yeggada Maruthi Areti Parandhama Chintha Madhavi M. C. S. Subha Kashayi Chowdojirao   

Open Access   

Published:  Dec 28, 2016

DOI: 10.7324/JAPS.2016.601202
Abstract

Flutamide (FLT) is a potent non-steroidal antiandrogen drug primarily used in palliative treatment of prostate cancer that inhibits androgen uptake and / or nuclear binding of androgen in target tissue. The present study gives, the experimental results on the successful encapsulation of Flutamide drug using Sodium Alginate (SA)/ Karaya gum (KG)) blend hydrogel membranes as controlled release (CR) polymer matrices. The Flutamide-containing polymer blend hydrogel membranes have been prepared by changing the experimental variables such as KG, SA and drug content by solution casting evaporation method. The membranes were characterized by swelling studies, FTIR, DSC, XRD, and SEM studies. The swelling results indicated that swelling of polymer membranes decrease with the increasing the amounts of Karaya gum. However, no significant variation in swelling was observed with different amounts of flutamide loading. The absence of chemical interactions between active ingredients and polymer was confirmed by FT-IR spectral measurements. Differential scanning calorimeter (DSC) and X-ray diffraction (XRD) studies were performed to understand the crystalline nature of drug after encapsulation into the Hydrogel membranes. Scanning electron microscopy (SEM) was used to study the surface morphology of the hydrogel membranes. The in vitro studies were carried out in phosphate buffer pH 7.4 at 37oC. The results of controlled release tests showed that the amount of Flutamide release increased with the increasing the amount of SA in the membrane. Moreover, the release rate of drug increased as the amount of drug loaded in the membranes increased. All the results indicated that the prepared membrane was potentially useful in drug delivery systems and the prolonged release rate was observed.


Keyword:     Interpenetrating Polymer Network Flutamide Encapsulation Karaya Gum.


Citation:

Nagarjuna G, Babu PK, Maruthi Y, Parandhama A, Madhavi C, Subha MCS, Chowdojirao K. Interpenetrating Polymer Network Hydrogel Membranes of Karayagum and Sodiumalginate for Control Release of Flutamide Drug. J App Pharm Sci, 2016; 6 (12): 011-019.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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