Research Article | Volume: 6, Issue: 11, November, 2016

Isolation and virtual screening of antimicrobial prodigiosin pigment from oxalotrophic Serratia marcescens OX_R strain

Mangesh V. Suryavanshi Samadhan R. Waghmode Nidhi Bharti Prafulla B. Choudhari Tejashri B. Hingamire Yogesh S. Shouche   

Open Access   

Published:  Nov 29, 2016

DOI: 10.7324/JAPS.2016.601108
Abstract

Prodigiosin a multifaceted secondary metabolite produced by Serratia spp. having great potential as a pharmaceutical. In the present study we demonstrate that oxalate supplementation in peptone glycerol production media increased organoleptic characters and yield of prodigiosin pigment extracted from oxalotrophic Serratia marcescens OX_R isolated from Indian bat guano sample. The pigment was demonstrated in-vitro as an antibacterial agent against common opportunistic skin surface pathogen Staphylococcus aureus NCIM 5021 strain as killing activity by agar well diffusion method. The docking analysis and pharmacophore modelling indicated that the probable mechanism of action of the prodigiosin was against Staphylococcus aureus DNA gyrase protein. The pigment was also found to efficiently dye both cotton and latex polymer. In summary, we describe here an oxalotrophic Serratia marcescens which may serve as a potent and economical resource of prodigiosin which owing to its dyeing and anti-bacterial activities finds future avenues to be developed as dressing material for nosocomial subjects or burn victim patients.


Keyword:     Oxalotrophic Serratia marcescens prodigiosin natural dyeing agent.


Citation:

Suryavanshi MV, Waghmode SR, Bharti N, Choudhari PB, Hingamire TB, Shouche YS. Isolation and virtual screening of antimicrobial prodigiosin pigment from oxalotrophic Serratia marcescens OX_R strain. J App Pharm Sci, 2016; 6 (11): 052-058.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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