Research Article | Volume: 6, Issue: 11, November, 2016

The Initiation Phase of Warfarin Therapy: Differences of Dose among Patients with Aortic Valve Replacement, Mitral Valve Replacement and Atrial Fibrillation

Teoh Chee Jia,  Aniza Abd Aziz,  Nadiah Wan-Arfah,  Nyi Nyi Naing   
Teoh Chee Jia1, Aniza Abd Aziz2, Nadiah Wan-Arfah1, Nyi Nyi Naing1

1Unit of Biostatistics and Research Methodology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.

2Faculty of Medicine, Universiti Sultan Zainal Abidin, Jalan Sultan Mahmud, 20400 Kuala Terengganu, Terengganu, Malaysia.

Open Access   

Published:  Nov 29, 2016

DOI: 10.7324/JAPS.2016.601105
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Abstract

This study was conducted to evaluate the changes in warfarin doses among patients after heart valve surgery and atrial fibrillation. A total of 137 patients having AF, AVR and MVR whom initiate warfarin therapy in year 2008 till 2010 in Penang Hospital were selected as samples for this study. Data collected included patient’s age, race, gender, warfarin initiation date, warfarin indication, warfarin dose and INR value for 1st till 12th weeks of warfarin initiation. Heart valve replacement patients (AVR or MVR) showed increasing trend in warfarin doses during the initial phase of warfarin therapy. This trend was not observed in AF patients. The dose of warfarin was significantly different within first 12 weeks of warfarin initiation for AVR and MVR group (p<0.001) but there was no significant difference in AF group. The dose of warfarin was significantly different among AVR and AF patients for first 5 weeks of warfarin initiation. Monitoring should be frequent for patients with heart valve replacement during the initial 3 months period of warfarin therapy.


Keyword:     Warfarin international normalized ratio atrial fibrillation.

Citation:

Teoh CJ, Aniza AA, Wan-Arfah B, Naing NN. The Initiation Phase of Warfarin Therapy: Differences of Dose among Patients with Aortic Valve Replacement, Mitral Valve Replacement and Atrial Fibrillation. J App Pharm Sci, 2016; 6 (11): 028-033.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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