Case Report | Volume: 6, Issue: 10, October, 2016

Clonazepam associated hypothyroidism: Aforethought on a concealed dilemma

Rupam GillDipanjan BhattacharjeeNavin A. PatilShripathy M. Bhat   

Open Access   

Published:  Oct 29, 2016

DOI: 10.7324/JAPS.2016.601031

Subclinical hypothyroidism or mild thyroid failure is a familiar problem, with a prevalence of 3-15% in a population without any known overt thyroid disorder. The prevalence increases with age and is relatively higher among females. Subclinical hypothyroidism is defined as serum thyroid stimulating hormone (TSH) levels above the upper limit of normal (4 mU/L) while the triiodothyronine (T3) and thyroxine (T4) enduring within the normal range. Additionally, there exists a log-linear relationship between TSH and circulating T3 and T4; hence, measurement of serum TSH becomes mandatory for diagnosing mild thyroid failure when free T3and T4 are lying within normal limits. Though, autoimmune thyroid disease is the most common cause for elevated TSH; thyroid functions can be afflicted by long-term consumption of drugs like lithium, amiodarone. The causal relationship between benzodiazepine class of drugs, particularly clonazepam and subclinical hypothyroidism has never been established clinically, yet there are some pre-clinical studies to claim the effect of benzodiazepine on thyroid functions; operating at various levels – hypothalamus, thyroid gland, peripheral cells and nuclear receptors. Henceforth, we would like to report a rare occurrence of subclinical hypothyroidism in an elderly female receiving clonazepam for her underlying psychiatric illness.

Keyword:     BenzodiazepineThyroid stimulating hormone (TSH)Naranjo’s algorithmTriiodothyronine (T3)Clonazepam.


Gill R, Bhattacharjee D, Patil NA, Bhat SM. Clonazepam associated hypothyroidism: Aforethought on a concealed dilemma. J App Pharm Sci, 2016; 6 (10): 222-225.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

HTML Full Text


Article Metrics
393 Views 43 Downloads 436 Total



Related Search

By author names