Research Article | Volume: 6, Issue: 10, October, 2016

Effect of high intensity interval training on 8-oxoguanine DNA glycosylase and 8-hydroxy-2'-deoxyguanosine contents in the brain and liver of rats

Ehsan Afroozi-Gerow Mohammad Esmaiel Afzalpour Hossein TaheriChadorneshin Seyed Hosein Abtahi-Eivary   

Open Access   

Published:  Oct 29, 2016

DOI: 10.7324/JAPS.2016.601023
Abstract

Production of reactive oxygen species (ROS) yields serious damage oxidation of proteins, lipids and genomic structures. Studies have shown that production of ROS increases during intensive exercise training. This study aimed to investigate the effect of high intensity interval training on 8-oxoguanine DNA glycosylase (OGG1) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels in the brain and liver of rats. 16 adult Albino Wistar rats were randomly divided into sedentary control and high intensity interval training groups. Animals ran on treadmill for 6 weeks, 6 days per week, at 95 to 100 percent of maximal oxygen consumption. Using commercial kits, the content of OGG1 and 8-OHdG were measured using sandwich ELISA assay. Data analyzed using Student’s T-test at P≤0.05 level. High intensity interval training resulted in significant increases in contents of OGG1 in brain (t14=7.22, P=0.001) and liver (t14=2.55, P=0.02) of rats. However, high intensity interval training had no significant influence on 8-OHdG levels in brain (t14=1.60, P=0.13) and liver (t14=1.28, P=0.22) of rats. Also, there were no significant differences between changes in the brain and liver contents of OGG1 (t14=0.97, P=0.34) and 8-OHdG (t14=0.42, P=0.68) of rats following high intensity interval training. Taken together, separation of the training sessions to various bouts of exercise with maximum effort, through increase in OGG1 contents, will lead to modify of 8-OHdG levels in brain and liver.




Citation:

Afroozi-Gerow E, Afzalpour ME, TaheriChadorneshin H, AbtahiEivary SH. Effect of high intensity interval training on 8- oxoguanine DNA glycosylase and 8-hydroxy-2'-deoxyguanosine contents in the brain and liver of rats. J App Pharm Sci, 2016; 6 (10): 170-173.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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