Research Article | Volume: 6, Issue: 8, August, 2016

Chemical Constituents of Dissotis perkinsiae (Melastomaceae) and Their Antimicrobial Activity

Tchebemou Bakang Bruno,  Nganso Ditchou Yves Oscar,  Soh Désiré,  Zondegoumba Nkwengoua Tchouboun Ernestine,  Toghueo Kouipou Rufin Marie,  Sidjui Sidjui Lazare,  Fekam Boyom Fabrice,  Schneider Bernd,  Nyasse Barthélémy   
Tchebemou Bakang Bruno1, Nganso Ditchou Yves Oscar2, Soh Désiré3, Zondegoumba Nkwengoua Tchouboun Ernestine1, Toghueo Kouipou Rufin Marie4, Sidjui Sidjui Lazare1, Fekam Boyom Fabrice4, Schneider Bernd5, Nyasse Barthélémy1

1Department of Organic Chemistry, Faculty of Science, University of Yaounde I, P.O.Box:812 Yaounde, Cameroon.

2Department of Chemistry, Faculty of Science, University of Maroua, P.O.Box: 814 Maroua, Cameroon.

3Department of Organic Chemistry, Higher Teachers Training College, University of Bamenda, P.O.Box: 39 Bambili, Cameroon.

4Department of Biochemistry, Faculty of Science, University of Yaoundé I, P.O.Box: 812 Yaoundé, Cameroon.

5Max Plant Institute for Chemical Ecology, Beutenberg Campus, Hans-Knol.8, D-07745 Jena, Germany

Open Access   

Published:  Aug 30, 2016

DOI: 10.7324/JAPS.2016.60815
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Abstract

The phytochemical study of the Methanol/dichloromethane extract of the leaves of Dissotis perkinsiae led to the isolation and identification seven compounds: Ursolic acid (1); Sitosterol-β-D-glucoside (2); Isoquercitrin (3); Quercetin-3-O-β-galactoside (4);Kaempferol-3-O-β-D-glucoside (5); Kaempferol-7-O-β-D-glucoside (6); Trans-Tiliroside (7). Their structures were elucidated on the basis of spectroscopic analysis and by comparison of their spectral data with those reported in the literature. The results of antimicrobial activity indicated that the MIC vary from >0.5 to 0.00078 mg/mL on yeasts and from >0.5 to 0.25 mg/mL on bacteria. Sitosterol-β-D-glucoside was the most active with the broad spectrum (MIC=0.125mg/mL on C. albicans, MIC=0.0625 mg/mL on C. kruseiand MIC=0.0078 mg/mL on C. parapsilosis). Kaempferol-7-O-β-D-glucoside was the most active on C. krusei (MIC=0.0039 mg/mL). The anti yeat activity of Sitosterol-β-D-glucoside and Kaempferol-7-O-β-D-glucoside were better thanfluconazole (0.032mg/mL) on C. parapsilosis (MIC 0.0078 mg/mL) and C. krusei (0.0039 mg/mL) respectively. Sitosterol-β-D-glucoside and Trans-Tiliroside showed weak inhibitotry activity against S. enteric and S. aureus with MIC value of 0.5mg/mL. Respectively this inhibitory effect was lower activities observed with Chloremphenicol and Ampicillin (0.000488 mg/mL). The results of this study suggest that Dissotis perkinsiae represent an untapped source of compounds with potential antimicrobial activity that could be explored in the development of new therapeutic natural products.


Keyword:     Dissotis perkinsiae Phytochemistry Antimicrobial activity.

Citation:

Bruno TB, Oscar NDY, Désiré S, Ernestine ZNT, Marie TKR, Lazare SS, Fabrice FB, Bernd S, Barthélémy N. Chemical Constituents of Dissotis Perkinsiae (Melastomaceae) and Their Antimicrobial Activity. J App Pharm Sci, 2016; 6 (08): 096-101.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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