Research Article | Volume: 6, Issue: 8, August, 2016

Amelioration of the nephrotoxic effect of potassium dichromate by whey protein and/or Nigella sativa oil in male albino rats

Samir A. E. Bashandy Mohamed M. Amin Fatma A. Morsy Salma A. El-Marasy   

Open Access   

Published:  Aug 30, 2016

DOI: 10.7324/JAPS.2016.60807
Abstract

Even though whey protein complex derived from milk, is being touted as a functional food with a number of health benefits, so far its full mechanistic effect has not been deeply explicated, which is the target of this study. For this reason, we observed the 2 months protection influence of whey protein (100 & 200 mg/kg, p.ob.wt.) and/or oil of Nigella sativa (5ml/kg, p.ob.wt.) against intoxicated rats with single dose of potassium dichromate (30mg/Kg, I.P) at the end of protection period. On the biochemical level, whey protein and/or oil of Nigella sativa were changed the potassium dichromate renal toxicity consequences, where it showed a significant improvement in the creatinine, urea, protein, uric acid and sodium levels. While in the tissue level (Kidney), it revealed a significant enhancement in reduced glutathione (GSH), catalase and superoxide dismutase (SOD) enzymes as compared to nephrotoxic group. Moreover, whey protein and/or oil of Nigella sativa reduced the elevation of malondialdehyde (MDA) and inflammatory mediators like tumor necrotic factor-alpha (TNF-α) and nitric oxide (NO) induced by potassium dichromate and alleviation the histopathological changes caused by the intoxication. These results give a new vision into the hopeful mechanisms that modulated numerous factors induced renal injury.


Keyword:     Whey protein oil of Nigella sativa potassium dichromate Nephrotoxicity.


Citation:

Bashandy SAE, Amin MM, Morsy FA, El-Marasy SA. Amelioration of the nephrotoxic effect of potassium dichromate by whey protein and/or Nigella sativa oil in male albino rats. J App Pharm Sci, 2016; 6 (08): 044-050.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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