Review Article | Volume: 6, Issue: 6, June, 2016

Role of Atorvastatin on Endothelial Cells and Endothelial Progenitor Cells in Cardiovascular Disease

Sampath Kumar,  Sujeetha Purushothaman,  Papitha Ponnaiya,  Keerthi Kishor,  Vijaya Anand   
Sampath Kumar1, Sujeetha Purushothaman2, Papitha Ponnaiya2, Keerthi Kishor2, Vijaya Anand2

1Department of Chemistry and Biosciences, SASTRA University, Kumbakonam, Tamil Nadu, India.

2Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, Tamil Nadu, India.

Open Access   

Published:  Jun 28, 2016

DOI: 10.7324/JAPS.2016.60627
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Abstract

The endothelium plays a key role in haemostatic balance. Endothelial progenitor cells (EPCs) are involved in the maintenance of endothelial haemostasis and in the process of blood vessel formation. Cardiovascular disease (CVD) is associated with reduced numbers and dysfunction of endothelial cells (ECs) and EPCs. Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-Co-A) reductase helps in restoring of EPCs and improvement of vascular function. This review underlines the pleiotropic effects of atorvastatin on ECs and EPCs.


Keyword:     Endothelial cells Endothelial Progenitor cells Atherosclerosis Atorvastatin.

Citation:

Sampath Kumar, Sujeetha Purushothaman, Papitha Ponnaiya, Keerthi Kishor, Vijaya Anand. Role of Atorvastatin on Endothelial Cells and Endothelial Progenitor Cells in Cardiovascular Disease. J App Pharm Sci, 2016; 6 (06): 151-154.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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