Research Article | Volume: 6, Issue: 6, June, 2016

In vitro trypanocidal activity of the Egyptian plant Schinopsis lorentizii against trypomastigote and amastigote forms of Trypanosoma cruzi

Khaled Rashed,  Daniele da Silva Ferreira,  Viviane Rodrigues Esperandim,  Maria Gabriela Marçal,  Breno Mumic Sequeira,  Lúzio Gabriel Bocalon Flauzino,  Wilson Roberto Cunha   
Khaled Rashed1, Daniele da Silva Ferreira2, Viviane Rodrigues Esperandim2, Maria Gabriela Marçal2, Breno Mumic Sequeira2, Lúzio Gabriel Bocalon Flauzino2, Wilson Roberto Cunha2

1Pharmacognosy Dept., National Research Centre, 33-El-Bohouth st. (former El-Tahrir st.)-Dokki, Giza, Egypt.

2Núcleo de Pesquisas em Ciências Exatas e Tecnológicas da Universidade de Franca, Franca, São Paulo, Brazil.

Open Access   

Published:  Jun 28, 2016

DOI: 10.7324/JAPS.2016.60610
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Abstract

Chagas’ disease is a chronic illness caused by the protozoan Trypanosoma cruzi. According to estimates, approximately 16-18 million people are infected in Latin American. Plant extracts exhibit a wide variety of secondary metabolites and can play an important role in the discovery of new compounds with biological potential. The in vitro trypanocidal activity of the extracts obtained from six plant species collected in Egypt (Parkia africana, Parkia roxburgi, Lagerstromeia speciosa, Schinopsis lorentzii, Lagerstromeia indica and Sapindus saponaria) was assayed against trypomastigote and amastigote forms of T. cruzi. The cytotoxic activity of the most active extract was also evaluated by conducting MTT assays. S. lorentzii and S. saponaria were the most active extracts against the trypomastigote form;IC50 values were 9.9 and 27.34 µg/mL, respectively. The S. lorentzii extract was also evaluated against the amastigote form (IC50 was 111.5 µg/mL).The S. lorentzii extract did not exhibit significant cytotoxic activity. The selectivity index value indicated that this extract was highly selective for the parasite. The S. lorentzii and S. saponaria extracts exhibit trypanocidal activity, probably as a result of the presence ofdifferent constituentsand their concentrations in the extracts.


Keyword:     Egyptian medicinal plants trypanocidal activity Trypanosoma cruzi phytoconstituents.

Citation:

Rashed K, Ferreira DDS, Esperandim VR, Marçal MG, Sequeira BM, Flauzino LGB, Cunha WR. In vitro trypanocidal activity of the Egyptian plant Schinopsis lorentizii against trypomastigote and amastigote forms of Trypanosoma cruzi. J App Pharm Sci, 2016; 6 (06): 055-060.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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